Relationships between erythrocyte aggregation, erythrocyte deformability, hematocrit, plasma viscosity and intracellular free calcium of erythrocyte.

Measurement of Erythrocyte Deformability

Microsieving diluted suspensions of oxygenated sickle cell anaemia (HbSS) cells on polycarbonate filters shows that piracetam improves the red cell deformability in vitro. In vivo an oral intake of 160 mg/kg/day divided in four doses enhances the HbSS cell deformability as actively as it does in in vitro experiments. The drug is also able partially to restore the impaired deformability of physi...

Erythrocyte deformability and hereditary elliptocytosis.

Hereditary elliptocytosis (HE) is a hereditary membranopathy that comprises a heterogeneous group of diseases, which share irreversible erythrocyte elongation with a prolonged longitudinal diameter in relation to the cross-section (elliptocytes and ovalocytes), which acts as a morphological sign to guide diagnosis. It is characterised by certain molecular alterations to cytoskeleton proteins, s...

In vitro hemorheological studies focusing on erythrocyte deformability and aggregation

Changes in erythrocyte aggregation and deformability during human ageing*

CURRENT SCIENCE, VOL. 82, NO. 2, 25 JANUARY 2002 191 *This paper is dedicated to Dr. R. Natarajan For correspondence. (e-mail: [email protected]) tuitum and M. parafortuitum have three clusters of mycolic acid peaks. The majority of the test isolates were identified as M. terrae, which has only two clusters, similar to M. diernhoferi. The good agreement between our HPLC results and thos...

Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows.

Concentrated erythrocyte (i.e., red blood cell) suspensions flowing in microchannels have been simulated with an immersed-boundary lattice Boltzmann algorithm, to examine the cell layer development process and the effects of cell deformability and aggregation on hemodynamic and hemorheological behaviors. The cells are modeled as two-dimensional deformable biconcave capsules and experimentally m...